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The combined quinone redox glutathione metabolism model can be used to simulate experimentally challenging scenarios such as potential redox cycling toxicity, while providing a platform from which quinone exposure and concentration toxicity experiments may be guided

Nishinaka T, Ichijo Y, Ito M, Kimura M, Katsuyama M, Iwata K, Miura T, Terada T, Yabe-Nishimura C (2007) Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element

This not only accelerates visible aging but also increases the risk of rosacea flare-ups