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According to another embodiment, the composition for use in treating oxidative stress in a subject in need thereof contains the Bacopa monniera extract containing 45% bacosides, the Silybum marianum (milk thistle) extract containing 70-80% Silymarin, the Withania somnifera (ashwagandha) extract in the form of a powder, the Camellia sinensis (green tea) extract containing 98% polyphenols and 45% EGCG, and the Curcuma longa (turmeric) extract containing 95% Curcuminin concentrations as detailed below in Table 2

Similarly, aspirin, a widely used Nonsteroidal Anti-inflammatory Drug (NSAID), can uncouple oxidative phosphorylation in liver mitochondria, suggesting a direct mitochondrial interaction (215)