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Unanswered Questions Regarding Weight Loss Mechanisms: Perspectives to Preclinical Research The exact mechanisms underlying the weight loss are still not clear, especially in light of the enhanced effects seen with multi-agonism, despite the large number of incretin agonists presently undergoing clinical trials and their remarkable effectiveness in managing obesity and T2DM [5, 14, 146, 147]

In L-NAME-treated rats, BPC-157 restored mucosal blood flow, while in L-arginine-excess models it attenuated hypotension 8