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Dans son cycle catalytique, la mthionine synthase transfre le groupe mthyle de la mthylcobalamine lhomocystine, produisant de la mthionine, puis le cofacteur est remthyl par le 5-mthyltetrahydrofolate, rgnrant la mthylcobalamine

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In a case study involving ME/CFS discordant identical twins, the affected twin showed reduced abundance of Bifidobacterium and Faecalibacterium compared to the non-affected twin, coupled with decreased gut alpha diversity [26]