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Cagrilintide Storage & Handling Cagrilintide Storage Reference State Lyophilized (powder) Storage -4F (-20C) freezer Duration Up to 24 months State Lyophilized (short-term) Storage 35.6-46.4F (2-8C) refrigerator Duration Acceptable for shipping or short storage State Reconstituted (liquid) Storage 35.6-46.4F (2-8C) refrigerator Duration 28-30 days

But once water is added, freezing becomes destructive

This collagen transition phase typically peaks around weeks two through four and resolves by week six to eight as new collagen matures and cross-links properly

Thats my take on this paper

Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix