After APAP administration, liver injury was detected in both KO and WT mice
A course of injections is highly recommended for B12, for example a course of 4 every few weeks to begin with, moving forward it can be repeated once every few months to ensure regular levels are maintained.
Common claims include powerful cognitive enhancement, treatment for cognitive decline and dementia, neurogenesis and synaptic plasticity support, seven orders of magnitude more potent than BDNF, and memory improvement and brain repair
Critics argue that trials supporting CBT and GET are heavily reliant on subjective outcomes (e.g., self-reported fatigue and physical function), resulting in highly inconsistent recovery rates (7%69%) that are determined by arbitrary thresholds
Continuous administration does not seem to provide additional benefit and may actually diminish the compound's effectiveness over time