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In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impaired lipid profile, insulin resistance, increased glucose levels, obesity, and cardiovascular disease), discussing whether IGF-1 replacement therapy could be a beneficial strategy for these patients

Some of those include metformin which is used in type 2 diabetes, heartburn medications that alter the production of stomach acid such as PPIs or H2 blockers, and oral contraceptives

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