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Despite these improvements, Roche decided to discontinue research into acmopatide and abandon plans for a phase 3 clinical trial

No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern

Consumer-facing claims about BPC-157 efficacy in humans for tendinopathy, joint pain, gastrointestinal disorders, or neurological conditions therefore extrapolate from rat and HUVEC work and are not supported by controlled human evidence

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