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A growing body of evidence suggests that these phytochemicals exert multi-targeted regulatory effects on bone regeneration by modulating key signaling pathways, including Wingless-related integration site (Wnt)/-catenin, Bone morphogenetic protein (BMP)/mothers against decapentaplegic homolog (Smad), Phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), and Nuclear factor erythroid 2related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)