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Aged recipients of SIRT3-overexpressing HSCs (T3 Tx) exhibited reduced numbers of CD68 + macrophages, F4/80 + tissue-resident macrophages, and CCR2 high inflammatory monocytes in the tissues, compared to mice transplanted with control HSCs (Cre Tx) (Extended Data Fig

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However, only the animals that were administered with the incretin-based compounds (GLP-1 and GLP-1MK-801) displayed increased baseline-corrected glucose-stimulated insulin secretion (Extended Data Fig

Weeks 1216+: Cumulative improvements continue

Work on exosomes and conditioned medium revealed that MSC-derived miR-17-5p, miR-126-3p and miR-664-5p can dampen oxidative stress, suppress caspase-3 and reactivate PI3K/AKT signalling in chemotherapy-damaged granulosa cells, suggesting cell-free products as next-generation therapeutics