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To explore this idea, we bred the MMTV-PyMT transgenic mouse strain (which spontaneously develops breast tumours) 26 with an uninduced Gclc f/f Rosa26 creERT2 mouse 27 in which the rate-limiting step in GSH synthesis, the glutamatecysteine ligase catalytic subunit (GCLC), can be knocked out throughout the body after induction with tamoxifen

Human studies typically involve a small number of sufferers or those who are pregnant

Panfili G, Manzi P, Pizzoferrato L

First, we will describe the mechanisms of action of the major active ingredients in functional foods in preventing and suppressing tumors, including their intervention in cancer development through antioxidant, anti-inflammatory, apoptosis-inducing, and tumor proliferation and metastasis-inhibiting pathways (Figure 2)

Consequently, low activation prevented proliferation in vitro (Supplementary Fig