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PubMed Central PMCID: PMC4531326

Together, these results suggested to us the possibility that NAC-induced roGFP2 oxidation is caused by sulfane sulfur (S 0 ) species created inside mitochondria, based on the following consideration (summarized in Figure 1E): It is known that H 2 S is very efficiently oxidized by sulfide:quinone oxidoreductase (SQR) to yield hydropersulfides inside the mitochondrial matrix (Libiad et al., 2014)

With IV, which was chosen for our patient due to poor PO tolerance and limited clarity around the time and quantity of ingestion, a loading dose (150 mg/kg administered over one hour) is then followed by tapered IV infusions over the next twenty hours (50 mg/kg administered over four hours, and 100 mg/kg administered over sixteen hours)

113 One combination option is the drug Thyrolar (Liotrix), which combines synthetic T4 and T3 in a fixed 4:1 ratio

Schachter J, Martel J, Lin CS, Chang CJ, Wu TR, Lu CC, et al