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In PCOS, oxidative stress contributes to: Hormonal disruption Insulin resistance Inflammation Poor skin recovery Pigmentation flare-ups Glutathione helps by: Reducing free radical damage Supporting cellular repair Calming stress-driven melanin activity This is why skin issues in PCOS often improve after internal balance improves , not before

Additionally, we studied the effect of performing a final washing step in distilled water (indicated as + 1 at the end of the sample code)

The central compartment is made up of the highly perfused tissues that equilibrate rapidly with the drug

When we compared the synthesized compound 2 ( 2 syn ) to its counterpart formed through the photo-oxidation of compound 1 ( 2 irr ), we observed no differences in their optical properties and stereochemistry (Supplementary Figs