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Tortuous, immature and unevenly perfused vessels create spatial heterogeneity in vascular access, oxygenation, acidity and drug distribution [11, 12, 15, 68]

Each may provide benefits on its own

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles

By contrast, a comparison of the effects of oral alpha-lipoic acid and placebo given for 7 months after intravenous alpha-lipoic acid administration for 3 weeks in 509 patients found no significant difference in total symptom score between alpha-lipoic acid and placebo [67]

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