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As a typical example, TCPP-based MOFs (TCPP: tetrakis (4-carboxyphenyl) porphyrin) are recognized as prospective nanophotosensitizers, such as Fe-TCPP, Mn-TCPP, and Cu-TCPP, which could be decomposed in overproduced GSH conditions, leading to intracellular GSH elimination (Wan et al., 2019

(Frontiers in Pharmacology, 2022) reports a half-life under 30 minutes after IM or IV administration in rodent and dog models, which is why split-dose schedules appear in the literature

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