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* Correspondence: Hua Liang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

A 2016 population-based cohort study published in BMJ (N=8,859 new pregabalin users) found a significantly elevated risk of road traffic accidents and falls in the first weeks of therapy [10]

Dopaminergic and noradrenergic systems are a more limited focus of study in LLD and in the case of the latter, may be due to challenges in radiotracer development

More research, particularly on ALCAR, is needed to understand the practical significance of this effect