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Association with outcomes and response to treatment of trimethylamine N-oxide in heart failure: results from BIOSTAT-CHF

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Treatment included 40 3-hour infusions of a multicomponent Na 2 EDTA solution, plus an oral, high-dose multivitamin/mineral supplement on nonchelation days

These findings align with observational links between higher follicular-fluid melatonin and better oocyte/embryo metrics, supporting a mechanistic redoxmitochondrial pathway