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Research Methodology 2.1

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In this approach, NO is generated from the donor compound 3-(2-hydroxy-1-methyl-ethyl-2-nitrosohydrazino)-N-methyl-1-propanamine, which is oxidized to NO2 by the target compound 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO)

191 In addition, O3,4,5-tri-caffeoylquinic acid enhances pigmentation by activating -catenin in follicular melanocytes and upregulating the expression of MITF, a target gene, in caffeoylquinic acid