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NNMT inhibitor for NAD+ metabolism & cellular energy research

318 (6), G1042G1053

Microbiome differences were greater between the two groups switched from WD to LD (i.e., WD/LD-V and WD/LD-T) and the two diet control groups (i.e., LD/LD-V and WD/WD-V) compared to the microbiome differences observed between the lean (LD/LD-V) and obese (WD/WD-V) control groups

By inhibiting NNMT, it leads to an increase in intracellular levels of NAD+ (nicotinamide adenine dinucleotide), a critical coenzyme for cellular metabolism and mitochondrial energy production

It is typically administered subcutaneously at 50100 mg daily in timed cycles, with noticeable energy and body-composition changes emerging within 38 weeks and side effects generally mild and transient