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Oxidative stress is involved in endothelial damage resulting from endothelial malfunction, which increases endothelial permeability and inflammatory cell infiltration in the arterial wall [69]

This process stimulates collagen and elastin production, proteins essential for maintaining skin elasticity and firmness

Diabetes Care 44 , 18351841 (2021)

Activation of the Nrf2/ARE pathway can mitigate these effects by enhancing the bodys antioxidant capacity and reducing inflammation