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Clinical features Most patients will initially present with no symptoms, or only mild gastrointestinal symptoms

The genes for inhibitors of the cell cycle (CDKN1, CDKN4D and ATM) are induced, whereas cyclins (proliferating cell nuclear antigen (PCNA), cyclin A, cyclin D1 and cyclin K) are downregulated during the period from 6 to 20 h [14]

Recently, worldwide efforts culminated in the creation of an ISO technical sub-committee (ISO/TC 276/SC 2) specifically tasked with identifying standardization needs and gaps in the field of microphysiological systems and OoC

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