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In addition, small molecule inhibitors including SLC7A11 inhibitor HG106 and GCLC inhibitor buthionine sulfoximine (BSO) were introduced to investigate their effects on ROS, GSH levels and cellular viability in VRK2-KO and VRK2-KD cells, and the results were consistent with the above knockdown experiment (Fig

Further investigations were carried out to understand the compound's impact on the contractile behavior of gastric smooth muscles, which were stimulated by acetylcholine and electrical field stimulation

Neurological disorders In conditions like Parkinsons and Alzheimers diseases, disruptions in cellular Ca 2+ regulating systems in the plasma membrane, ER, and mitochondria can manifest in synaptic dysfunction, decreased plasticity, and neuronal degeneration [286,287,288]