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However, it is important to note that the vast majority of this data comes from animal models, and human clinical trial data remains limited

thelancet.com Wilding JPH, et al

Al, obese Zucker rats were received a dose of 500 micrograms/kg of body weight over the course of 19 days

The increased lipolysis by isoproterenol alone (in the absence of co-treatment with insulin) in Insr P1195L/ +/HFD adipocytes also suggests that some factors [such as activities of perilipin 9 and/or adipocyte triglyceride lipase 10 (ATGL)] other than insulin-dependent suppression of phospho-HSL may contribute to the increased lipolysis 11