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Approaches such as intrathecal, intracerebroventricular, and intraparenchymal injections, as well as transient BBB disruption, have been employed to deliver drugs with limited CNS bioavailability (Rezaee et al., 2025)

Zhang Y, Wang P, Xia C, Wu Z, Zhong Z, Xu Y, et al

Some NHS/ICB guidance notes oral options for dietary-related deficiency, and that long-term injection schedules depend on the cause

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