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The combination therapy showed slightly better scores in WOMAC and Lequesne indices than HA alone, but not enough to support strong clinical superiority (Nouri et al., 2022)

doi: 10.3389/fmicb.2025.1536778 477 HuLSunLYangCZhangDWWeiYYYangMMet al

Chronic metabolic conditions are characterized by: Increased production of reactive oxygen species Impaired antioxidant defenses Mitochondrial dysfunction Chronic inflammation Cellular damage to pancreatic -cells, adipocytes, and hepatocytes How GLP-1 Affects Oxidative Stress Research has revealed that GLP-1 receptor agonists exert antioxidant effects through several mechanisms: Direct antioxidant signaling: Activation of the GLP-1 receptor triggers cellular pathways that reduce ROS production Anti-inflammatory effects: Decreases production of pro-inflammatory cytokines that contribute to oxidative stress Mitochondrial protection: Improves mitochondrial function and reduces oxidative damage Endothelial function: Enhances nitric oxide production and vascular health However, during weight loss especially rapid weight loss induced by GLP-1 RAs patients may experience increased oxidative stress due to the mobilization of stored toxins from adipose tissue

If you want hyaluronic acid or vitamin C, apply them separately after the peptides absorb to maintain efficacy