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Organic oxidants promote mitochondrial lipid peroxidation and ROS accumulation tBHP also induced lipid peroxidation in the mitochondrial fraction as assessed by a mitochondria-targeted fluorescent sensor mitoPeDPP (Fig

Thereby, PI3K and AKT transcription was downregulated 1.7- and 2-fold, respectively, whereas PGC-1 transcripts were increased 7-fold and AKT phosphorylation was reduced by 3550%

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