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Metformin improves peripheral but not hepatic insulin action in obese patients with type II diabetes

Lancet 390, 15501562

Aspirin helps a little with the headache

The added expense and inconvenience may outweigh unproven benefits compared to optimizing GLP-1 dosing and lifestyle factors alone

In practice, most interest clusters around these real world goals: Skin quality and visible aging Wound healing support (when appropriate), which aligns with the principles of regenerative therapy Hair and scalp health conversations (still evolving, mixed quality evidence) Joint, tendon, connective tissue support as part of a bigger plan Recovery support, again in context And for some patients, the longevity benefit is simply this: better tissue repair capacity and less chronic inflammatory signaling can improve quality of life