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The resulting imbalance may chemically alter: The body uses several layers of antioxidant defense

Editor's Pick Glutathione and Vitamin C: Do They Work Together

In the presence of ferrous or cuprous ions, H 2 O 2 can become a hydroxyl radical, which is very reactive and causes oxidation of lipids, proteins, and DNA, resulting in damage to the cell

When NRF2 translocates to the nucleus, it binds antioxidant response elements (AREs) in the promoter regions of GST genes, upregulating their expression

These well-characterized findings show that immature red blood cells suffer ferroptosis stress from iron accumulation and oxygen during stress erythropoiesis, while ferroptosis is rarely detectable in normal red blood cells