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In contrast, a small fraction of lymphoma and leukemia cell lines successfully grow in these gels [28, 30], suggesting the presence of TIC or TIC-like cells even in established lymphoma/leukemia cell lines cultured in vitro

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Covalent modification of human proteins by such chemicals, or protein haptenation, is a common occurrence in cells and may result in generation of antigenic species, leading to development of hypersensitivity reactions

DOI: 10.1016/s0021-9150(00)00724-3 54