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For digestive issues, symptom scores, inflammatory markers, and potentially repeat endoscopy or permeability testing help assess response

Study Period: 17 days Notes: This protocol is typically administered twice per year

Substances like cobalt or the iron chelator desferrioxamine, which have been applied in HepG2 cells to mimic hypoxia-induced gene expression, interact on various sides of the oxygen-sensing pathway, confirming the importance of b-type cytochromes and the Fenton reaction

Side effects are typically mild and short lasting, with less than 5% of patients requiring dose reduction or discontinuation

both of these do, so pairing them does not offset that concern