These include promoting short-chain fatty acid (SCFA) production, reshaping microbial diversity and community composition, and inducing functional shifts in microbial metabolism, particularly SCFA-related and other energy-regulating pathways
When endogenous neurons are ablated through apoptosis, resulting in minimal reactive gliosis and inflammation, tNs can achieve near-perfect integration with appropriate brain-wide synaptic inputs and functional properties comparable to endogenous neurons (Falkner et al., 2016)
These therapies interact with natural pathways involved in appetite and glucose balance, and are prescribed following a medical evaluation
Preclinical studies have indicated the potential efficacy of this approach across a range of diseases, including ischemia-reperfusion injury, neurodegenerative disorders, kidney diseases, acute respiratory distress syndrome, and cancer [124, 138,139,140,141,142,143]
& Shoham, Z.) 302316 (CRC Press, 2023)