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This occurs because GSSG has reduced aqueous solubility compared to GSH, and advanced oxidation products form insoluble aggregates

However, this does not necessarily mean LL-37 itself is harmful

Accumulation of waste products, specifically lactate, and decreased oxygen concentrations result in alternations in the microenvironment of the IVD hindering the anabolic process of proteoglycan synthesis

A small fraction, however, takes a different route and forms a compound called NAPQI

Factors that cause glutathione depletion and accelerate aging include: Nutrient-deficient diet Pollutants in the air and water Environmental toxins in food and personal care products Prescription medications and recreational drugs Chronic stress Trauma Infections Exposure to radiation Minimizing your exposure to harmful elements and optimizing healthy lifestyle behaviors can help prevent glutathione depletion