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Cerivastatin, approved by the FDA in 1997, was withdrawn from the market just four years later after 52 deaths as a result of severe rhabdomyolysis 4

Phase I metabolism involves enzymes such as cytochrome P450 (CYP) enzymes, flavin-containing monooxygenases (FMO), alcohol dehydrogenases, and esterases, among others

doi: 10.2174/15748847113089990048

As mentioned, a pro-inflammatory state is required to recruit peripheral immune cells into the brain parenchyma, and dysregulation within this process can promote neurodegeneration (Scheld et al., 2016)

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