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doi: 10.3389/fendo.2021.578802 168 KleinNAAndersenRNCassonPRBusterJEKramerRE

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It was concluded that HA08 binds to IRAP in a very similar conformation to what was proposed by the MD simulations ( The metathesis reaction was applied to obtain a series of macrocyclic compounds, devoid of the reactive disulfide function and with the potential to become oral bioavailable and more metabolically stable (Marsault and Peterson, 2011)