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In the present review, discussion will be limited to well-studied phytochemicals that operate by affecting the Nrf2/Keap1 system

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Circulation 103, 27992804

Upon binding to its receptor RANK on pre-osteoclasts, RANKL activates several downstream cascades, including MAPK family memberssuch as ERK, c-Jun N-terminal kinase (JNK), and p38which subsequently induce the expression of nuclear factor of activated T cells c1 (NFATc1), the master transcription factor for osteoclast-specific gene expression (Huang et al., 2006)

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