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ROS include O 2 , H 2 O 2 , and hydroxyl radicals (OH ) (Fig

In cells that survive treatment, 5FU promotes a sustained increase in mitochondrial content over 72 h, as shown by changes in levels of nonyl-acridine orange (NAO) staining (Fig

These effects occur through mechanisms including enhanced angiogenesis, modulation of growth factor expression, and direct cytoprotection of gastric epithelial cells

In addition, cerebral inflammation is known to be a key component of some neurologic diseases including Alzheimers disease, multiple sclerosis, and migraine (19)

These findings have generated interest in hair restoration applications, though translating results from rodent dorsal skin to human scalp remains speculative without clinical validation (Pickart & Margolina, 2018)