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a delivery system free of first pass effect include transdermal, nasal, buccal or sublingual, suppositories and injectables Under this aspect, a delivery system is such that it delivers GHK- Cu peptide in various release pattern so as to provide continuous supply of GHK- Cu over extended periods

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It is hypothesized that CSD, which results in migraine, may be caused by increased neuronal excitability (Sparaco et al., 2006)