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doi: 10.3389/fpsyt.2025.1587432 Received 05 March 2025 Accepted 17 September 2025 Published 23 October 2025 Volume 16 - 2025 Edited by Antonio Narzisi, Stella Maris Foundation (IRCCS), Italy Reviewed by Stefano Marini, Independent Researcher, Termoli, Italy Yitzchak Frank, Mount Sinai Hospital, United States Updates Copyright 2025 Wang and Sun

Some benefits like reduced inflammation and improved recovery may appear within days, while complete tissue regeneration and structural healing continue developing over the full 6-12 week protocol and beyond

If children return too quickly to the activity that has caused a stress fracture, it may lead to chronic problems such as harder-to-heal stress fractures

The additional cost of adding TB-500 often proves worthwhile when faster, more complete healing matters