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NNMT plays a pivotal role in regulating cellular metabolism

A recent randomized controlled trial indicated that vitamin B12 supplementation significantly decreased serum levels of homocysteine compared to placebo, while no significant difference was revealed in between-group comparisons for fasting blood glucose, malondialdehyde, and liver steatosis ( This MR analysis showed no association between genetic prediction of vitamin B12 concentrations and liver enzymes, which indicated that vitamin B12 was possibly unable to affect NAFLD risk through the pathways involved in liver enzymes

Semaglutide does not directly affect intrinsic factor production, but the reduced stomach acid environment can compromise the initial separation step that makes b12 available for intrinsic factor binding

However, chronic GH treatment carries substantial risks, including glucose intolerance, insulin resistance, diabetes, cancer, and cardiovascular complications

Vitamin B12 also helps prevent megaloblastic anemia, a blood condition that makes people tired and weak