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Interestingly, many antidepressant drugs increase the availability of the precursors (tryptophan and serotonin) and the major pineal neurotransmitter NE and therefore stimulate melatonin secretion

the residence time is approximately 1 h (Weber and Quicker 2018)

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Fourthly, the severity of the IVD degeneration possibly influences the therapeutic effect of injected cells and/or growth factors, since degenerated CLCs may have lost their chondrogenic potential and the effect of injected cells and/or growth factors may differ between early and severely degenerated IVDs [90]