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At the same time, EGT can also selectively inhibit the activity of some Zn- and Cu-requiring metalloenzymes, thus inhibiting the oxidation of these metal ions and preventing them from participating in the formation of ROS in the body ( Owing to its antioxidant properties, EGT plays a powerful cytoprotective role in some important cells and tissues ( 2 O 2 and hemoglobin on arachidonic acid (Spicer et al., 1951

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Future directions may involve integrating gene-editing and nanotechnology approaches to precisely regulate CUL5 within immune cells, aiming to overcome critical bottlenecks in solid tumor therapy

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doi:10.3389/fendo.2022.968215