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Transfusion-dependent -thalassemia patients may experience brain iron overload, potentially leading to cognitive impairment, in contrast to non-transfusion-dependent patients [43]

5.2 GPX4 activators As a key regulator of ferroptosis, glutathione peroxidase 4 (GPX4) plays a critical role in preventing lipid peroxidation and maintaining cellular homeostasis

The lipids (oily fatty acids) form our cell membranes so that their non-polar tails face inward away from the polar cytoplasm and the polar heads face towards the polar cytoplasm

RF drafted the manuscript

Research has found that TAM-derived TGF-1 regulates the expression of hepatic leukemia factor (HLF) by modulating SMAD3, resulting in transactivation of gamma-glutamyltransferase 1 (GGT1)