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4.4 Decrease of N-acetylaspartate/creatine Hyperglycemia plays a crucial role in the onset of early cognitive decline by inducing reductions in myelination and the decrease in the cerebral content of N-acetyl aspartate (NAA) and creatine ratio, a significant marker of neuronal and axonal loss (106)

In a therapy known as autologous chondrocyte implantation (ACI), doctors harvest a patient's chondrocytes (cartilage cells), which are then multiplied outside the body and returned to the damaged joint

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Fragmentation pathways may involve cleavage at amide bonds, producing characteristic fragment ions corresponding to partial backbone structures