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The survey found that 78.8% of patients had an overall positive experience, 12% had adverse effects, and 86% of patients found the nasal spray to be easy to use

Zhang, C., Wu, W., Li, X., Xin, X

In humans, the biotin-requiring enzymes include acetyl-CoA carboxylase (ACC: humans express two distinct ACC genes), pyruvate carboxylase (PC), propionyl-CoA carboxylase (PCC), and 3-methylcrotonyl-CoA carboxylase (3MCC)

Adjei AA, Gaedigk A, Simon SD, Weinshilboum RM, Leeder JS: Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects

Researchers should consult the primary literature and follow their institution's biosafety and chemical-handling protocols