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10.1016/j.lfs.2005.12.010 19

EM generally is typically characteristic by the appearance of both macular and papular typical targetoid lesions (with three zones of color, as opposed to atypical targetoid lesions which have two) and papular atypical targetoid lesions, all of which are generally absent in SJS/TEN which only has macular atypical targetoid lesions [68]

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In animal studies, chronic stress can lead to structural and functional changes in some neural correlates of pain perception or pain modulation, notably in the hippocampus, which may concomitantly affect cognitive functions 2,19

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