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After PEG modification, it can not only bind closely to albumin, cover the enzymatic hydrolysis site of DPP-4, but also reduce renal excretion, prolong the biological half-life, and achieve the effect of long circulation

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All experiments were approved by the Local Ethics Committee

(2023) 186:27482764.e22

Fischer HS, Zernig G, Schatz DS, Humpel C, Saria A (2000) MDMA ('ecstasy) enhances basal acetylcholine release in brain slices of the rat striatum