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Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition

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Safety: NAC is well tolerated in both short- and long-term studies (NIH)

GH oversecretion (acromegaly) is linked to a higher incidence of neuropsychiatric diseases in humans (108110)

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