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Subjects were monitored at baseline, at 1 month, and after 23 months of continuous daily supplemental l-carnitine ingestion by examination of the rate of plasma appearance of both d 3 -TMAO (Figure 4A) and d 3 -BB (Figure 4C) following oral d 3 -l-carnitine challenge

TGR5 regulates macrophage inflammation in nonalcoholic steatohepatitis by modulating NLRP3 inflammasome activation

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Acknowledgements We thank Colleen McHugh and Harriet Pratley for the generation of GspD/PilQ antisera, Jos Muoz-Dorado for providing plasmids for copper-inducible gene expression, Tm Mignot, Emilia Mauriello, and Penelope Higgs for providing carbohydrate deletion strains, Daniel Bollschweiler, Florian Beck, and Harald Engelhardt (MPI of Biochemistry, Martinsried) for their help with averaging the negatively stained A