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Besides their well-known pivotal role in peptide bound formation, C domains have been reported to catalyze ester bound formation and may also have dual functions by acting as epimerization and condensation domain 26,27,28

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This phase 2 study compared brodalumab against placebo in patients with active PsA (both non-exposed and exposed to prior biologic therapy) to a primary endpoint of 20% improvement of American College of Rheumatology (ACR) criteria at week 12

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