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Three RCTs met inclusion criteria The trials randomized 153 participants (74 participants to oral vitamin B12 and 79 participants to IM vitamin B 12 )

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Selected Data 1) The research study conducted by the research team of Kwon and Park aimed to evaluate the protective effects of the peptide AOD9604 when administered via intra-articular injection on cartilage in a collagenase-induced osteoarthritis (OA) rabbit model

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The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) tool was used to assess the certainty of the evidence for the two primary biochemical outcomesserum vitamin B12 concentration increase and homocysteine reductionacross all included studies, and separately for randomised controlled trials (RCTs) and observational studies